Testing Hardy-Weinberg equilibrium with a simple root-mean-square statistic
نویسندگان
چکیده
منابع مشابه
Testing Hardy-Weinberg equilibrium with a simple root-mean-square statistic.
We provide evidence that, in certain circumstances, a root-mean-square test of goodness of fit can be significantly more powerful than state-of-the-art tests in detecting deviations from Hardy-Weinberg equilibrium. Unlike Pearson's $\chi ^2$ test, the log-likelihood-ratio test, and Fisher's exact test, which are sensitive to relative discrepancies between genotypic frequencies, the root-mean-sq...
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Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
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When the classical chi(2) goodness-of-fit test for Hardy-Weinberg (HW) equilibrium is used on samples with related individuals, the type I error can be greatly inflated. In particular the test is inappropriate in population isolates where the individuals are related through multiple lines of descent. In this article, we propose a new test for HW (the QL-HW test) suitable for any sample with rel...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2013
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxt028